The influence of various coatings of hydroxyapatite bone carrier on the success of bone regeneration in rabbit calvarial defects: Histomorphometric and histological analysis

Background/Aim. The materials used nowadays for bone replacement do not fully meet the requirements complete regeneration, which is why new ones are being tested. Despite numerous attempts to improve tissue no fulfilling material has been found yet. This study investigated influence of poly-lactide-co-glycolide (PLGA) and polyethyleneimine (PEI) as coatings hydroxyapatite (HAP) carriers on regenerative potential in rabbits? calvarial defect. Methods. Calvarial defects measuring 6 mm diameter were made 19 skeletally mature rabbits. Defects filled with one following materials: PLGA coated HAP (HAP + PLGA), PEI PEI), bovine ? Bio-Oss? (positive control). Unfilled represented negative control. Histological analysis was performed order determine inflammatory response host tissue. formation evaluated using histomorphometric analysis. All analyses have conducted samples obtained 3, 6, 9 weeks after implantation. Results. Three post-implantation, a trend toward increased healing group compared other noticed, statistically significant difference between groups (p > 0.05). However, weeks, observed favor < Within this group, greater groups. Conclusion. demonstrated coating respect osteogenesis improvement reconstructive surgery.